Denosy® contains S-adenosylmethionine (SAMe), a precursor to the potent antioxidant Glutathione that protects hepatic cells from toxins and death. It is recommended to improve hepatic glutathione levels in patients to help maintain and protect liver function^3,4. Denosyl® may also be used in other areas of tissue oxidative injury caused by certain toxins or drugs which are related to reduced glutathione concentrations.⁴ Denosy®, however, goes beyond increasing glutathione levels and has been shown to protect liver cells from cell death and may be useful in cell regeneration.^1,5

• 강아지와 고양이의 간 해독 메커니즘을 돕습니다.
• 특정 약물에 의한 조직 산화적 손상 및 혈구의 취약성 등 다른 이유로도 사용될 수 있습니다.
• 일부 약물에 의한 간 부작용을 막을 수 있습니다.
• Very high safety profile ^1,3,4
• Also, supports healthy brain function in senior dogs

간에 대해 알아보기

The liver is one of the largest organs in the body and performs many life-essential functions. It produces a vast number of hormones, enzymes, proteins, and other substances important for your pet’s life and well-being. It also detoxifies and removes waste products in the bloodstream by changing them to a form that can be eliminated. This filtering of waste products is important because toxins can damage the membranes of cells in the liver and other organs. The most important liver “detoxifier” is glutathione, a potent antioxidant and the liver’s first line of defense.

항산화 요법

Both dogs and cats make glutathione from S-adenosylmethionine (SAMe). SAMe is formed naturally by the liver from the amino acid methionine, found in your pet’s diet. When the liver is compromised, production of SAMe decreases resulting in less glutathione.1 This further compromises liver function. A study of dogs and cats with various liver function problems reported that many had low liver glutathione levels.²

주요 성분 및 기능

장용성 코팅된 정제로 활성 성분 S-아데노실메티오닌(SAMe)이 함유되어 있습니다.

사용 방법

PAW Denosyl® is used as adjunctive treatment for liver diseases or dysfunction, such as the following:

• 만성 간염
• 간 지방증
• 흉강염 간염
• 파라세타몰 독성
• Corticosteroid use (Note: does not prevent corticosteroid-induced hepatic vacuolar change)
• 간세포 독소 및 종양 형성을 포함한 기타 급성 또는 만성 간장애

복용량 및 관리

Absorption of Denosyl® is decreased when it is given with a meal. For optimal absorption, administer Denosyl® at least one hour before feeding your pet. For owners who find it difficult to administer tablets to their pets, Denosyl®tablet(s) may be disguised in a small bite of moist food. It is not necessary to withhold water from your pet when giving Denosyl®
In cats, tablets or capsules can “stick” in the throat instead of passing into the stomach. Therefore, cat owners should gently administer a small amount of water (ask your veterinarian for details) immediately following tablet administration to aid swallowing.
 
Denosyl® tablets should not be broken as the enteric coating of the Denosyl® tablet protects the active ingredient from destruction while in the stomach.
 
정제의 수는 필요에 따라 언제든지 점차적으로 줄이거나 늘릴 수 있습니다. 복용량을 늘리거나 줄이려면 전체 태블릿 단위로 조정해야합니다.
 
대부분 매일 또는 3일마다 투여하는 경우 장기간 효과가 유지됩니다.

참고 문헌

1. Center SA. Proceedings of the 18th ACVIM, Seattle, WA, 2000; 550-552.
2. Center SA. Proceedings of TNAVC, Orlando, FL 2001; 218-219.
3. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66(2):330-341.
4. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005; 19 : 303-314.
5. Webster CRL, Boria P, Usechak P, Anwer MS. Vet Therapeutics 2002; 3 (4) : 474-484.
6. Center SA, Warner KL, Erb HN. Am J Vet Res 2002;63(8):1187-1197.